LRP8 anticorps (Middle Region)

N° du produit ABIN2781811

Détail du produit anti-LRP8 anticorps

Antigène: LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Mouton, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP8 est non-conjugé

Application: Western Blotting (WB)

Séquence: NRKMLIFSTD FLSHPFGVAV FEDKVFWTDL ENEAIFSANR LNGLEIAILA

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 92%, Sheep: 93%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against Lrp8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 996 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LRP8

Antigène: LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))

Autre désignation: Lrp8 (LRP8 Produits)

Synonymes: anticorps LRP8, anticorps APOER2, anticorps HSZ75190, anticorps LRP-8, anticorps MCI1, anticorps 4932703M08Rik, anticorps AA921429, anticorps AI848122, anticorps ApoER2, anticorps Lr8b, anticorps LR8B, anticorps LDL receptor related protein 8, anticorps low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, anticorps LRP8, anticorps Lrp8

Sujet: Lrp8 is the cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Lrp8 binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Lrp8 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. Lrp8 may also function as an endocytic receptor.
Alias Symbols: 4932703M08Rik, AA921429, AI848122, Lr8b, apoER2, ApoER2
Protein Interaction Partner: Dab1, Mapk8ip1, Mapk8ip2, Snx17,
Protein Size: 996

Poids moléculaire: 110 kDa

ID gène: 16975

NCBI Accession: NM_053073, NP_444303

UniProt: Q924X6