TGFBR2 anticorps (N-Term)

N° du produit ABIN2781999

Détail du produit anti-TGFBR2 anticorps

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Porc, Mouton, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFBR2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SDVEMEAQKD EIICPSCNRT

Homologie: Cow: 93%, Goat: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 93%, Sheep: 91%

Attributs du produit: This is a rabbit polyclonal antibody against TGFBR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 567 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TGFBR2

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Autre désignation: TGFBR2 (TGFBR2 Produits)

Synonymes: anticorps AAT3, anticorps FAA3, anticorps LDS1B, anticorps LDS2B, anticorps MFS2, anticorps RIIC, anticorps TAAD2, anticorps TGFR-2, anticorps TGFbeta-RII, anticorps 1110020H15Rik, anticorps AU042018, anticorps DNIIR, anticorps RIIDN, anticorps TBR-II, anticorps TbetaR-II, anticorps TbetaRII, anticorps TGFBR2, anticorps TBETA-RII, anticorps TGFBRII, anticorps TGF-beta 2, anticorps Tgfbr2T, anticorps cb537, anticorps tgfbr2, anticorps wu:fj05c10, anticorps zgc:110498, anticorps transforming growth factor beta receptor 2, anticorps transforming growth factor, beta receptor II, anticorps transforming growth factor, beta receptor 2, anticorps transforming growth factor beta receptor 2b, anticorps TGFBR2, anticorps Tgfbr2, anticorps tgfbr2b

Sujet: TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Protein Interaction Partner: TRAF4, NRP1, NRP2, TGFB1, TERT, PEG10, ENG, GOPC, IQGAP1, UBC, RCVRN, PDGFRA, APP, TGFBR1, MAP3K7, PAK1, OCLN, SMAD7, CDC42, Hsp90aa1, KCNK18, FBXO34, PPP1R16B, OXSR1, ARHGEF6, TRAF6, TSC22D1, SMURF1, OSR1, TCTEX1D4, SNX6, TSSK1B, TGFBRAP1, TRAP1, STRAP,
Protein Size: 567

Poids moléculaire: 62 kDa

ID gène: 7048

NCBI Accession: NM_003242, NP_003233

UniProt: P37173