ACVR1 anticorps (N-Term)

N° du produit ABIN2782109

Cet anticorps Lapin Polyclonal détecte spécifiquement ACVR1 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Chévre et Cobaye.

Aperçu rapide pour ACVR1 anticorps (N-Term) (ABIN2782109)

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Chévre, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACVR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ACVR1 anticorps

Épitope: N-Term

Séquence: TCKTPPSPGQ AVECCQGDWC NRNITAQLPT KGKSFPGTQN FHLEVGLIIL

Homologie: Cow: 100%, Dog: 93%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ACVR1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 509 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ACVR1

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Autre désignation: ACVR1

Sujet: Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Alias Symbols: ACTRI, ACVRLK2, ALK2, FOP, SKR1, TSRI, ACVR1A
Protein Interaction Partner: UBC, USP15, BMPR1A, ACVR1, INHBA, ACVR2A, PEG10, SMAD6, SMAD7, BAMBI, SMURF1, IGSF1, TSC22D1, TGFBR1, DCAF6, FGD6, FCHO1, PLEK, TTC17, RHEBL1, WDR61, RASL12, RASD2, PLEKHJ1, CDK14, NEK8, DUSP13, NUAK2, FKBP4, RAB6B, RAB17, UBXN1, FBXO30, RHOJ, PLEKHB1, UB
Protein Size: 509

Poids moléculaire: 55 kDa

ID gène: 90

NCBI Accession: NM_001105, NP_001096

UniProt: Q04771