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ACVR2B anticorps (Middle Region)

ACVR2B Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Mouton, Cobaye, Poisson zèbre (Danio rerio), Lapin, Chévre WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2782111
  • Antigène Voir toutes ACVR2B Anticorps
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Épitope
    • 15
    • 9
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 72
    • 30
    • 30
    • 10
    • 9
    • 7
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Mouton, Cobaye, Poisson zèbre (Danio rerio), Lapin, Chévre
    Hôte
    • 70
    • 7
    • 3
    Lapin
    Clonalité
    • 75
    • 5
    Polyclonal
    Conjugué
    • 37
    • 12
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACVR2B est non-conjugé
    Application
    • 75
    • 28
    • 23
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    KSKNVLLKSD LTAVLADFGL AVRFEPGKPP GDTHGQVGTR RYMAPEVLEG
    Homologie
    Cow: 100%, Dog: 100%, Goat: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 77%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against ACVR2B. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human ACVR2B
    Top Product
    Discover our top product ACVR2B Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 512 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Autre désignation
    ACVR2B (ACVR2B Produits)
    Synonymes
    anticorps ACVR2B, anticorps XAR1, anticorps actr-iib, anticorps actriib, anticorps ACTRIIB, anticorps ActR-IIB, anticorps HTX4, anticorps ActRIIB, anticorps actr2b, anticorps actrIIb, anticorps wu:fj97d11, anticorps activin A receptor type 2B, anticorps activin A receptor type 2B L homeolog, anticorps activin A receptor type 2Ba, anticorps activin receptor IIB, anticorps ACVR2B, anticorps acvr2b, anticorps acvr2b.L, anticorps Acvr2b, anticorps acvr2ba
    Sujet
    Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
    Alias Symbols: ACTRIIB, ActR-IIB, MGC116908, HTX4
    Protein Interaction Partner: GDF2, BMP10, INHBA, PEG10, ERBB2IP, HSP90AA1, SMAD7, SMAD6, SMAD2, IGSF1, SYNJ2BP, SNX6, SNX2, TGFBRAP1, GDF11, MSTN, ACVR1B, SNX1, INHBC, GDF5, INHBB, BMP7, BMP2, ENG, BMP6,
    Protein Size: 512
    Poids moléculaire
    58 kDa
    ID gène
    93
    NCBI Accession
    NM_001106, NP_001097
    UniProt
    Q13705
    Pathways
    Hormone Transport, Cancer Immune Checkpoints
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