ATP2A2 anticorps (C-Term)

N° du produit ABIN2782136

Détail du produit anti-ATP2A2 anticorps

Antigène: ATP2A2 (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Lapin, Chien, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: VNLVTDGLPA TALGFNPPDL DIMNKPPRNP KEPLISGWLF FRYLAIGCYV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ATP2A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ATP2A2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1042 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ATP2A2

Antigène: ATP2A2 (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2))

Autre désignation: ATP2A2 (ATP2A2 Produits)

Synonymes: anticorps atp2b, anticorps ca-p60a, anticorps dar, anticorps serca2, anticorps ATP2A2, anticorps ATP2B, anticorps DAR, anticorps DD, anticorps SERCA2, anticorps SERCA2A, anticorps ATP2, anticorps Serca2, anticorps SercaII, anticorps 9530097L16Rik, anticorps D5Wsu150e, anticorps SERCA2B, anticorps mKIAA4195, anticorps atp2a2, anticorps zgc:55380, anticorps ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog, anticorps ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2, anticorps ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, anticorps ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a, anticorps atp2a1.S, anticorps ATP2A2, anticorps Atp2a2, anticorps atp2a2a

Sujet: ATP2A2 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in two transcript variants encoding different isoforms.
Alias Symbols: ATP2B, DAR, DD, DKFZp686P0211, FLJ20293, FLJ38063, MGC45367, SERCA2
Protein Interaction Partner: ERLIN2, UBC, SUMO2, SPRTN, PTPLAD1, LGR4, MDM2, ASB14, ASB5, ASB17, ASB1, TRIM13, SUZ12, RNF2, EZH2, rev, S100A1, EGFR, ADRB2, ILK, CLN5, CLN3, env, NOS2, ATF2, CFTR, MDC1, ECT2, SLC3A2, ITPR3, CUL3, FBXO25, SPP1, SIRT7, ELAVL1, SUMO1, AMFR, HDAC5, CAMK2A
Protein Size: 1042

Poids moléculaire: 115 kDa

ID gène: 488

NCBI Accession: NM_170665, NP_733765

UniProt: P16615

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Ribonucleoside Biosynthetic Process