COL6A1 anticorps (Middle Region)

N° du produit ABIN2782366

Détail du produit anti-COL6A1 anticorps

Antigène: COL6A1 (Collagen, Type VI, alpha 1 (COL6A1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COL6A1 est non-conjugé

Application: Western Blotting (WB)

Séquence: ADITILLDGS ASVGSHNFDT TKRFAKRLAE RFLTAGRTDP AHDVRVAVVQ

Homologie: Cow: 93%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against COL6A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human COL6A1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1028 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur COL6A1

Antigène: COL6A1 (Collagen, Type VI, alpha 1 (COL6A1))

Autre désignation: COL6A1 (COL6A1 Produits)

Synonymes: anticorps CBR, anticorps SDR21C1, anticorps hCBR1, anticorps OPLL, anticorps AI747156, anticorps Col6a-1, anticorps RGD1565398, anticorps COL6A1, anticorps carbonyl reductase 1, anticorps collagen type VI alpha 1 chain, anticorps collagen, type VI, alpha 1, anticorps collagen, type VI, alpha 1 L homeolog, anticorps collagen type VI alpha 3 chain, anticorps collagen alpha-1(VI) chain, anticorps CBR1, anticorps COL6A1, anticorps Col6a1, anticorps col6a1.L, anticorps COL6A3, anticorps col6a1, anticorps LOC100623720

Sujet: COL6A1 is a collagen VI which acts as a cell-binding protein.Defects in COL6A1 are a cause of Bethlem myopathy (BM).The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. This gene, which encodes a neural small non-messenger RNA, is a member of the family of interspersed repetitive DNA, and its product represents an example of a primate tissue-specific RNA polymerase III transcript. The RNA sequence is divided into three domains: a 5' portion homologous to the Alu Lm, a central adenosine-rich region, and the terminal 43-nt nonrepetitive domain. It is believed that this gene was retropositionally generated and recruited into a function regulating dendritic protein biosynthesis. At least two pseudogenes of this gene have been identified. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-200 AF020057.2 4262-4461
Alias Symbols: OPLL
Protein Interaction Partner: PDGFB, PDGFA, PDIA3, FBXO6, UBC, VHL, DNAJB11, LGALS3BP, LAMB1, FGF7, COL2A1, MAG, DCN,
Protein Size: 1028

Poids moléculaire: 106 kDa

ID gène: 1291

NCBI Accession: NM_001848, NP_001839

UniProt: P12109

Pathways: Growth Factor Binding, SARS-CoV-2 Protein Interactome