RFC3 anticorps (C-Term)

N° du produit ABIN2782474

Détail du produit anti-RFC3 anticorps

Antigène: RFC3 (Replication Factor C (Activator 1) 3, 38kDa (RFC3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFC3 est non-conjugé

Application: Western Blotting (WB)

Séquence: IIMKGLLSEL LHNCDGQLKG EVAQMAAYYE HRLQLGSKAI YHLEAFVAKF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against RFC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human RFC3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 356 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RFC3 (ABIN2782474)

You, Li, Kim, Kang, Koh, Chwae, Kim, Kim, Park, Jang, Kim: "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors." dans: PLoS biology, Vol. 5, Issue 5, pp. e109, (2007) (PubMed).

Détails sur RFC3

Antigène: RFC3 (Replication Factor C (Activator 1) 3, 38kDa (RFC3))

Autre désignation: RFC3 (RFC3 Produits)

Synonymes: anticorps CG5313, anticorps DRFC, anticorps DmRFC3, anticorps Dmel\\CG5313, anticorps Rfc3, anticorps 21.m02902, anticorps 2810416I22Rik, anticorps 38kDa, anticorps AU022547, anticorps Recc3, anticorps cb275, anticorps RFC38, anticorps Replication factor C subunit 3, anticorps replication factor C3, anticorps replication factor C subunit 3, anticorps replication factor C 38 kDa subunit, anticorps DNA replication factor C complex subunit Rfc3, anticorps replication factor C3, putative, anticorps replication factor C (activator 1) 3, anticorps replication factor C subunit 3 L homeolog, anticorps RfC3, anticorps PF14_0601, anticorps Chro.30359, anticorps PB000006.01.0, anticorps PC000345.04.0, anticorps TP04_0380, anticorps Tb09.211.3310, anticorps PY04255, anticorps PVX_117300, anticorps BBOV_IV003080, anticorps SJAG_02182, anticorps PKH_124240, anticorps rfc3, anticorps Rfc3, anticorps RFC3, anticorps rfc3.L

Sujet: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. RFC3 is the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: MGC5276, RFC38
Protein Interaction Partner: PCNA, TP53, UBC, RPA3, RPA2, RPA1, RPP40, FBXO6, ARFGAP1, VCP, RFC4, RFC5, RFC2, RFC1, PURB, PURA, MCM3, Cebpb, RAD21, HDGF, SMARCAD1, EBNA-LP, MESDC2, MYC, FAN1, MEPCE, USP20, CHTF8, RAD17, BRD4, CHTF18,
Protein Size: 356

Poids moléculaire: 40 kDa

ID gène: 5983

NCBI Accession: NM_002915, NP_002906

UniProt: P40938

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA