MTHFD1 anticorps (Middle Region)

N° du produit ABIN2782515

Détail du produit anti-MTHFD1 anticorps

Antigène: MTHFD1 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Cheval, Poisson zèbre (Danio rerio), Porc, Chien, Cobaye, Boeuf (Vache), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTHFD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: CMAKTHLSLS HNPEQKGVPT GFILPIRDIR ASVGAGFLYP LVGTMSTMPG

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MTHFD1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MTHFD1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 935 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MTHFD1

Antigène: MTHFD1 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1))

Autre désignation: MTHFD1 (MTHFD1 Produits)

Synonymes: anticorps MTHFC, anticorps MTHFD, anticorps Tb07.27M11.970, anticorps Dcs, anticorps E430024A07Rik, anticorps Mthfd, anticorps GB13160, anticorps cb325, anticorps fc29f07, anticorps mthfd1, anticorps wu:fc29f07, anticorps zgc:55597, anticorps methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, anticorps C-1-tetrahydrofolate synthase, cytoplasmic, anticorps putative C-1-tetrahydrofolate synthase, cytoplasmic, anticorps putative C-1-tetrahydrofolate synthase,cytoplasmic, anticorps methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like, anticorps methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase, anticorps methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b, anticorps c-1-tetrahydrofolate synthase, cytoplasmic, anticorps methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase L homeolog, anticorps methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase, anticorps MTHFD1, anticorps Mthfd1, anticorps Tc00.1047053509509.20, anticorps Tc00.1047053511741.50, anticorps Tc00.1047053511517.60, anticorps Tc00.1047053508207.240, anticorps Tb927.7.1600, anticorps LINJ_26_0310, anticorps LBRM_26_0350, anticorps LMJF_26_0320, anticorps mthfd1l, anticorps LOC550749, anticorps mthfd1b, anticorps Tsp_00651, anticorps mthfd1.L, anticorps mthfd1, anticorps LOC589933, anticorps LOC100634307

Sujet: MTHFD1 possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MTHFC, MTHFD
Protein Interaction Partner: UBC, FUS, SUMO2, SUMO3, NEDD8, MDM2, RPA3, RPA2, RPA1, RNF2, RPS21, MAT2A, UBQLN1, FBXO6, UBD, ADRB2, CD81, VCAM1, HSP90AA1, HSP90AB1, PRKCDBP, SFXN1, TMEM165, IARS2, SARS2, SF3B3, FAF2, PPT2, SNRNP70, RPL32, MRPL23, ALDH18A1, PRPH, PC, ICT1, GAA, ACSL3,
Protein Size: 935

Poids moléculaire: 101 kDa

ID gène: 4522

NCBI Accession: NM_005956, NP_005947

UniProt: P11586

Pathways: Methionine Biosynthetic Process