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DCC anticorps (Middle Region)

DCC Reactivité: Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2782671
  • Antigène Voir toutes DCC Anticorps
    DCC (Deleted in Colorectal Carcinoma (DCC))
    Épitope
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 47
    • 36
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)
    Hôte
    • 56
    • 5
    Lapin
    Clonalité
    • 56
    • 5
    Polyclonal
    Conjugué
    • 27
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DCC est non-conjugé
    Application
    • 45
    • 33
    • 16
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    PIGQMHPPHG SVTPQKNSNL LVIIVVTVGV ITVLVVVIVA VICTRRSSAQ
    Homologie
    Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against DCC. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human DCC
    Top Product
    Discover our top product DCC Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 1447 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    DCC (Deleted in Colorectal Carcinoma (DCC))
    Autre désignation
    DCC (DCC Produits)
    Synonymes
    anticorps CRC18, anticorps CRCR1, anticorps IGDCC1, anticorps MRMV1, anticorps DCC, anticorps zdcc, anticorps C030036D22Rik, anticorps Igdcc1, anticorps xdcc, anticorps XDCCa, anticorps dcca-A, anticorps Dcc, anticorps DCC netrin 1 receptor, anticorps deleted in colorectal carcinoma, anticorps netrin receptor DCC, anticorps DCC, anticorps dcc, anticorps Dcc, anticorps LOC100712666
    Sujet
    This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
    Alias Symbols: CRC18, CRCR1, IGDCC1
    Protein Interaction Partner: UBC, ALB, BARD1, sina, UBI4, SIAH2, EIF4E3, EIF2A, EIF5A2, NTN1, RPL23, EIF2S2, EIF2B2, EIF2B4, EZR, RPS24, RPS13, RPS10, RPS6, RPS4X, RPL38, RPL28, RPL13, RPL5, PTK2, MAPK1, RPL10A, EIF3E, EIF4E, EIF2S3, EIF2B1, EIF1AX, ADORA2B, APPL1, CASP9, SIAH1, MAPK
    Protein Size: 1447
    Poids moléculaire
    158 kDa
    ID gène
    1630
    NCBI Accession
    NM_005215, NP_005206
    UniProt
    P43146
    Pathways
    Regulation of Cell Size
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