CYP1B1 anticorps (Middle Region)

N° du produit ABIN2784612

Détail du produit anti-CYP1B1 anticorps

Antigène: CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP1B1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AVANVMSAVC FGCRYSHDDP EFRELLSHNE EFGRTVGAGS LVDVMPWLQY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CYP1B1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CYP1B1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 543 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CYP1B1 (ABIN2784612)

Staršíchová, Hrubá, Slabáková, Pernicová, Procházková, P?n?íková, Seda, Kabátková, Vondrá?ek, Kozubík, Machala, Sou?ek: "TGF-?1 signaling plays a dominant role in the crosstalk between TGF-?1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells." dans: Cellular signalling, Vol. 24, Issue 8, pp. 1665-76, (2012) (PubMed).

Wang, Hawkins, Miller: "Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 2, pp. 644-52, (2011) (PubMed).

Détails sur CYP1B1

Antigène: CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))

Autre désignation: CYP1B1 (CYP1B1 Produits)

Synonymes: anticorps CP1B, anticorps CYPIB1, anticorps GLC3A, anticorps P4501B1, anticorps P4501b1, anticorps CYP1B1, anticorps CYP1B, anticorps zgc:136223, anticorps cytochrome P450 family 1 subfamily B member 1, anticorps cytochrome P450, family 1, subfamily b, polypeptide 1, anticorps cytochrome P450, family 1, subfamily B, polypeptide 1, anticorps cytochrome P450 1B1, anticorps CYP1B1, anticorps Cyp1b1, anticorps cyp1b1, anticorps LOC100719054

Sujet: CYP1B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1B1 localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma, therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma, therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CP1B, GLC3A, P4501B1, CYPIB1
Protein Interaction Partner: UBC, SAE1,
Protein Size: 543

Poids moléculaire: 61 kDa

ID gène: 1545

NCBI Accession: NM_000104, NP_000095

UniProt: Q16678

Pathways: Steroid Hormone Biosynthesis