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JAK3 anticorps (Middle Region)

JAK3 Reactivité: Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Chien WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2785645
  • Antigène Voir toutes JAK3 Anticorps
    JAK3 (Janus Kinase 3 (JAK3))
    Épitope
    • 16
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 88
    • 49
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Chien
    Hôte
    • 84
    • 6
    Lapin
    Clonalité
    • 69
    • 21
    Polyclonal
    Conjugué
    • 33
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp JAK3 est non-conjugé
    Application
    • 50
    • 29
    • 23
    • 14
    • 14
    • 11
    • 8
    • 8
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF
    Homologie
    Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human JAK3
    Top Product
    Discover our top product JAK3 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 1124 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    JAK3 (Janus Kinase 3 (JAK3))
    Autre désignation
    JAK3 (JAK3 Produits)
    Synonymes
    anticorps JAK-3, anticorps JAK3_HUMAN, anticorps JAKL, anticorps L-JAK, anticorps LJAK, anticorps fae, anticorps wil, anticorps RATJAK3, anticorps JAK, anticorps Janus kinase 3, anticorps JAK3, anticorps Jak3
    Sujet
    JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
    Protein Interaction Partner: Socs5, KIT, IL7R, TYK2, STAT6, STAT3, JAK2, JAK1, IL4R, GTF2B, ERBB3, CDK1, CD81, APOA1, UBC, SOCS3, UHRF2, STAT5A, IKBKG, ALK, SH2B2, TIAF1, INPP5D, PTPN2, STAM2, PRMT5, SOCS1, KHDRBS1, STAM, PTK2B, IRS2, SHB, JAK3, IL2RG, VIL1, FES, CD247, PTPN6, PIK3R1
    Protein Size: 1124
    Poids moléculaire
    125 kDa
    ID gène
    3718
    NCBI Accession
    NM_000215, NP_000206
    UniProt
    P52333
    Pathways
    Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
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