JAK3 anticorps (Middle Region)
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- Antigène Voir toutes JAK3 Anticorps
- JAK3 (Janus Kinase 3 (JAK3))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JAK3 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF
- Homologie
- Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human JAK3
- Top Product
- Discover our top product JAK3 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1124 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- JAK3 (Janus Kinase 3 (JAK3))
- Autre désignation
- JAK3 (JAK3 Produits)
- Synonymes
- anticorps JAK-3, anticorps JAK3_HUMAN, anticorps JAKL, anticorps L-JAK, anticorps LJAK, anticorps fae, anticorps wil, anticorps RATJAK3, anticorps JAK, anticorps Janus kinase 3, anticorps JAK3, anticorps Jak3
- Sujet
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JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Protein Interaction Partner: Socs5, KIT, IL7R, TYK2, STAT6, STAT3, JAK2, JAK1, IL4R, GTF2B, ERBB3, CDK1, CD81, APOA1, UBC, SOCS3, UHRF2, STAT5A, IKBKG, ALK, SH2B2, TIAF1, INPP5D, PTPN2, STAM2, PRMT5, SOCS1, KHDRBS1, STAM, PTK2B, IRS2, SHB, JAK3, IL2RG, VIL1, FES, CD247, PTPN6, PIK3R1
Protein Size: 1124 - Poids moléculaire
- 125 kDa
- ID gène
- 3718
- NCBI Accession
- NM_000215, NP_000206
- UniProt
- P52333
- Pathways
- Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
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