KPNA2 anticorps (Middle Region)

N° du produit ABIN2785824

Détail du produit anti-KPNA2 anticorps

Antigène: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA2 est non-conjugé

Application: Western Blotting (WB)

Séquence: GTDEQTQVVI DAGALAVFPS LLTNPKTNIQ KEATWTMSNI TAGRQDQIQQ

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KPNA2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KPNA2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 529 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KPNA2

Antigène: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Autre désignation: KPNA2 (KPNA2 Produits)

Synonymes: anticorps IPOA1, anticorps QIP2, anticorps RCH1, anticorps SRP1alpha, anticorps ima2, anticorps importin, anticorps 2410044B12Rik, anticorps PTAC58, anticorps Rch1, anticorps ipoa1, anticorps kpna2, anticorps qip2, anticorps rch1, anticorps srp1alpha, anticorps hm:zeh0389, anticorps hm:zeh0389r, anticorps zgc:113902, anticorps zgc:86945, anticorps karyopherin subunit alpha 2, anticorps importin subunit alpha-2, anticorps Importin subunit alpha-2, anticorps karyopherin (importin) alpha 2, anticorps karyopherin alpha-2 subunit like L homeolog, anticorps karyopherin alpha 2 (RAG cohort 1, importin alpha 1), anticorps KPNA2, anticorps EDI_246290, anticorps EDI_335040, anticorps ima2, anticorps Kpna2, anticorps kpna2.L, anticorps kpna2

Sujet: Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IPOA1, QIP2, RCH1, SRP1alpha
Protein Interaction Partner: NUP50, HOMEZ, TRIM54, NECAB2, SERTAD3, NUP62, RBPMS, HMG20A, HUWE1, MAGED1, UBC, TADA2A, MLH1, MDFI, FUS, AP2B1, INO80E, NUTM1, KRT40, PNMA5, LZTS2, USHBP1, NMNAT1, GMCL1, HNRNPC, SMAD6, rev, KPNA4, HSP90AB1, PRMT1, ACLY, COPS4, KPNA6, CDK11A, SRPK1, CLK3
Protein Size: 529

Poids moléculaire: 58 kDa

ID gène: 3838

NCBI Accession: NM_002266, NP_002257

UniProt: P52292

Pathways: M Phase, Protein targeting to Nucleus