SESN1 anticorps (Middle Region)

N° du produit ABIN2786032

Détail du produit anti-SESN1 anticorps

Antigène: SESN1 (Sestrin 1 (SESN1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SESN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: KWLNGLENAP QKLQNLGELN KVLAHRPWLI TKEHIEGLLK AEEHSWSLAE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against SESN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human SESN1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SESN1

Antigène: SESN1 (Sestrin 1 (SESN1))

Autre désignation: SESN1 (SESN1 Produits)

Synonymes: anticorps zgc:91970, anticorps sestrin-1, anticorps SESN1, anticorps XPA26, anticorps pa26, anticorps sest1, anticorps PA26, anticorps SEST1, anticorps 1110002G11Rik, anticorps AU044290, anticorps Pa26, anticorps Sest1, anticorps sesn1-A, anticorps sestrin 1, anticorps sestrin 1 L homeolog, anticorps SESN1, anticorps sesn1, anticorps Sesn1, anticorps sesn1.L

Sujet: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: PA26, SEST1
Protein Interaction Partner: UBC, RBX1, KEAP1, SQSTM1, PRDX1,
Protein Size: 551

Poids moléculaire: 64 kDa

ID gène: 27244

NCBI Accession: NM_014454, NP_055269