NSMCE2 anticorps (Middle Region)

N° du produit ABIN2786320

Détail du produit anti-NSMCE2 anticorps

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Épitope: Middle Region

Reactivité: Humain, Souris, Lapin, Cheval, Cobaye, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSMCE2 est non-conjugé

Application: Western Blotting (WB)

Séquence: KFLALQSKNS DADFQNNEKF VQFKQQLKEL KKQCGLQADR EADGTEGVDE

Homologie: Cow: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NSMCE2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 247 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NSMCE2

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Autre désignation: NSMCE2 (NSMCE2 Produits)

Synonymes: anticorps 1110014D18Rik, anticorps AI661537, anticorps RGD1305156, anticorps C8orf36, anticorps MMS21, anticorps NSE2, anticorps ZMIZ7, anticorps Non-SMC element 2, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog, anticorps Smc5-6 complex non-SMC subunit 2, anticorps Nsmce2, anticorps NSMCE2, anticorps nsmce2.L, anticorps nse2

Sujet: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Alias Symbols: C8orf36, FLJ32440, MMS21, NSE2
Protein Interaction Partner: TXLNA, PAN2, UBC, NSMCE1, SMC6, PDS5A, SMC5, WAPAL, PDS5B, STAG2, SMC3, SMC1A, SUMO1, TSNAX, RAD21, ETV1, SUMO2,
Protein Size: 247

Poids moléculaire: 28 kDa

ID gène: 286053

NCBI Accession: NM_173685, NP_775956

UniProt: Q96MF7