Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (N-Term) anticorps

Détails pour le produit réf. ABIN2787801
Antigène
  • FSGS2
  • TRP6
  • AV025995
  • LLHWJM002
  • LLHWJM003
  • LLHWJM004
  • TRP-6
  • Trrp6
  • mtrp6
  • trp6
  • bZ1P14.9
  • si:rp71-1p14.9
  • trpc6
  • transient receptor potential cation channel subfamily C member 6
  • transient receptor potential cation channel, subfamily C, member 6
  • transient receptor potential cation channel, subfamily C, member 6a
  • TRPC6
  • Trpc6
  • trpc6a
  • trpc6
Épitope
N-Term
38
19
6
3
2
2
2
1
1
1
1
1
1
1
Reactivité
Cheval, Humain, Souris, Rat (Rattus)
99
58
33
7
5
4
3
3
2
2
2
1
Hôte
Lapin
77
42
6
1
1
Clonalité
Polyclonal
Conjugué
Inconjugué
4
4
4
4
4
4
Application
Western Blotting (WB)
104
60
37
13
12
5
3
2
2
2
1
Options
Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human TRPC6
Blocking Peptide Blocking peptide for this product available: ABIN985627
Séquence MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC
Homologie Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
Attributs du produit This is a rabbit polyclonal antibody against TRPC6. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigène
Autre désignation TRPC6 (TRPC6 Antibody Extrait)
Sujet TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Alias Symbols: FLJ11098, FLJ14863, FSGS2, TRP6
Protein Interaction Partner: RNF24, TRPC3, ORAI1, TRPM2, TRPC6, SRC, ITPR3, MX1, FYN, TRPC7, TRPC5, TRPC4, TRPC1, TRPC2, ITPR1,
Protein Size: 931
Poids moléculaire 106 kDa
ID gène 7225
NCBI Accession NM_004621, NP_004612
UniProt Q9Y210
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 931 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (N-Term) antibody (ABIN2787801) WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positi...
Background publications Liu, Maier, Scholze, Rauch, Boltzen, Zhao, Zhu, Tepel: "High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 4, pp. 746-51, 2008 (PubMed).

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