MRGPRX1 anticorps (C-Term)

N° du produit ABIN2788263

Détail du produit anti-MRGPRX1 anticorps

Antigène: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRGPRX1 est non-conjugé

Application: Western Blotting (WB)

Séquence: FLSALNSSAN PIIYFFVGSF RQRQNRQNLK LVLQRALQDA SEVDEGGGQL

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MRGPRX1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MRGPRX1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 322 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MRGPRX1

Antigène: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Autre désignation: MRGPRX1 (MRGPRX1 Produits)

Synonymes: anticorps GPCR, anticorps MRGX1, anticorps SNSR4, anticorps MrgC11, anticorps Mrgprc11, anticorps Snsr1, anticorps MAS related GPR family member X1, anticorps MAS-related GPR, member X1, anticorps MRGPRX1, anticorps Mrgprx1

Sujet: MRGPRX1 is an orphan receptor. MRGPRX1 is probably involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain. MRGPRX1 is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. MRGPRX1 is activated by the antimalarial drug, chloroquine and may mediate chloroquine-induced itch, in an histamine-independent manner.
Alias Symbols: GPCR, MRGX1, SNSR4
Protein Interaction Partner: GNG2, GNB1, GNAQ, GNAI2,
Protein Size: 322

Poids moléculaire: 36 kDa

ID gène: 259249

NCBI Accession: NM_147199, NP_671732

UniProt: Q96LB2