CYP3A5 anticorps (N-Term)

N° du produit ABIN2788347

Détail du produit anti-CYP3A5 anticorps

Antigène: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP3A5 est non-conjugé

Application: Western Blotting (WB)

Séquence: AITDPDVIRT VLVKECYSVF TNRRSLGPVG FMKSAISLAE DEEWKRIRSL

Homologie: Cow: 79%, Dog: 91%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 82%, Pig: 93%, Rat: 79%, Sheep: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CYP3A5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CYP3A5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 502 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CYP3A5

Antigène: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Autre désignation: CYP3A5 (CYP3A5 Produits)

Synonymes: anticorps CP35, anticorps CYPIIIA5, anticorps P450PCN3, anticorps PCN3, anticorps cytochrome P450 family 3 subfamily A member 5, anticorps CYP3A5

Sujet: This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: CP35, P450PCN3, PCN3, CYPIIIA5
Protein Interaction Partner: RDH13, ATOH8, ETV5,
Protein Size: 502

Poids moléculaire: 57 kDa

ID gène: 1577

NCBI Accession: NM_000777, NP_000768

UniProt: P51589

Pathways: Steroid Hormone Biosynthesis