HLA-DMA anticorps (N-Term)
-
- Antigène Voir toutes HLA-DMA Anticorps
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
-
Épitope
- N-Term
- Reactivité
- Humain, Rat, Lapin, Chien
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp HLA-DMA est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
- Homologie
- Dog: 77%, Human: 100%, Rabbit: 82%, Rat: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against HLA-DMA. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA
- Top Product
- Discover our top product HLA-DMA Anticorps primaire
-
-
- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
-
Antigen size: 261 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Antigène
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- Autre désignation
- HLA-DMA (HLA-DMA Produits)
- Synonymes
- anticorps RT1.Ma, anticorps RT1.DMa, anticorps HLA-DMA, anticorps H-2Ma, anticorps H2-Ma, anticorps D6S222E, anticorps DMA, anticorps HLADM, anticorps RING6, anticorps RT1 class II, locus DMa, anticorps SLA-DM alpha chain, anticorps major histocompatibility complex, class II, DM alpha, anticorps histocompatibility 2, class II, locus DMa, anticorps RT1-DMa, anticorps SLA-DMA, anticorps DLA-DMA, anticorps H2-DMa, anticorps HLA-DMA
- Sujet
-
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: B3GAT1, U2AF2, RUNX1, UBC, CD82, HLA-DRB1, HLA-DOA, HLA-DRA, HLA-DMB, CD74,
Protein Size: 261 - Poids moléculaire
- 29 kDa
- ID gène
- 3108
- NCBI Accession
- NM_006120, NP_006111
- UniProt
- Q31604
- Pathways
- Cancer Immune Checkpoints
-