TNFSF9 anticorps (C-Term)
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- Antigène Voir toutes TNFSF9 Anticorps
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNFSF9 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against TNFSF9. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product TNFSF9 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 254 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
- Autre désignation
- TNFSF9 (TNFSF9 Produits)
- Synonymes
- anticorps TNFSF9, anticorps 4-1BB-L, anticorps 4-1BBL, anticorps AI848817, anticorps Cd137l, anticorps Ly63l, anticorps CD137L, anticorps TNF superfamily member 9, anticorps tumor necrosis factor (ligand) superfamily, member 9, anticorps Tnfsf9, anticorps LOC476729, anticorps TNFSF9
- Sujet
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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Alias Symbols: 4-1BB-L, CD137L
Protein Interaction Partner: TIRAP, TLR4, IRAK2, UBC, TNFRSF9, TRAF2, TRAF1,
Protein Size: 254 - Poids moléculaire
- 28 kDa
- ID gène
- 8744
- NCBI Accession
- NM_003811, NP_003802
- UniProt
- P41273
- Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
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