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HLA-DOB anticorps (N-Term)

HLA-DOB Reactivité: Humain, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Mouton WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2788876
  • Antigène Voir toutes HLA-DOB Anticorps
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Épitope
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 24
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Mouton
    Hôte
    • 18
    • 6
    Lapin
    Clonalité
    • 21
    • 3
    Polyclonal
    Conjugué
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HLA-DOB est non-conjugé
    Application
    • 17
    • 9
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    LTRLDSSMTQ GTDSPEDFVI QAKADCYFTN GTEKVQFVVR FIFNLEEYVR
    Homologie
    Cow: 79%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 93%, Rabbit: 86%, Sheep: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against HLA-DOB. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human HLA-DOB
    Top Product
    Discover our top product HLA-DOB Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeat freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Autre désignation
    HLA-DOB (HLA-DOB Produits)
    Synonymes
    anticorps DOB, anticorps major histocompatibility complex, class II, DO beta, anticorps HLA-DOB, anticorps PATR-DOB
    Sujet
    HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
    Alias Symbols: DOB
    Protein Interaction Partner: HLA-DMB, CD82, CD63,
    Protein Size: 273
    Poids moléculaire
    30 kDa
    ID gène
    3112
    NCBI Accession
    NM_002120, NP_002111
    UniProt
    Q5QNS2
    Pathways
    Cancer Immune Checkpoints
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