HLA-DMB anticorps (N-Term)

N° du produit ABIN2789474

Détail du produit anti-HLA-DMB anticorps

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Épitope: N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DMB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FTYCISFNKD LLTCWDPEEN KMAPCEFGVL NSLANVLSQH LNQKDTLMQR

Homologie: Human: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against HLA-DMB. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 263 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HLA-DMB

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Autre désignation: HLA-DMB (HLA-DMB Produits)

Synonymes: anticorps RING7, anticorps D6S221E, anticorps RT1.DMb, anticorps RT1.Mb, anticorps MHC-DMB, anticorps major histocompatibility complex, class II, DM beta, anticorps RT1 class II, locus DMb, anticorps HLA-DMB, anticorps RT1-DMb, anticorps PATR-DMB

Sujet: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Alias Symbols: D6S221E, RING7
Protein Interaction Partner: CUL3, TEAD1, MDM2, DPM2, CD82, HLA-DOB, CD63, HLA-DRA, HLA-DMA, CD74,
Protein Size: 263

Poids moléculaire: 29 kDa

ID gène: 3109

NCBI Accession: NM_002118, NP_002109

UniProt: P28068

Pathways: Cancer Immune Checkpoints