RRP8 anticorps (N-Term)

N° du produit ABIN2791071

Détail du produit anti-RRP8 anticorps

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Épitope: N-Term

Reactivité: Humain, Rat, Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRP8 est non-conjugé

Application: Western Blotting (WB)

Séquence: GKKGKKKCQK QGPPCSDSEE EVERKKKCHK QALVGSDSAE DEKRKRKCQK

Homologie: Cow: 83%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 456 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RRP8

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Autre désignation: RRP8 (RRP8 Produits)

Synonymes: anticorps KIAA0409, anticorps 1500003O22Rik, anticorps 2900001K19Rik, anticorps AW538116, anticorps RGD1308302, anticorps ribosomal RNA processing 8, anticorps ribosomal RNA processing 8, methyltransferase, homolog (yeast), anticorps RRP8, anticorps Rrp8

Sujet: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Alias Symbols: KIAA0409
Protein Interaction Partner: RNF2, SIRT7, SIRT1, SUV39H1, USP39,
Protein Size: 456

Poids moléculaire: 50 kDa

ID gène: 23378

NCBI Accession: NM_015324, NP_056139

UniProt: O43159