NSMCE4A anticorps (C-Term)

N° du produit ABIN2791705

Détail du produit anti-NSMCE4A anticorps

Antigène: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Épitope: C-Term

Reactivité: Humain, Souris, Lapin, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSMCE4A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: PVIQEERAMP AQLRRMEESH QEATEKEVER ILGLLQTYFR EDPDTPMSFF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NSMCE4A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human NSMCE4A

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NSMCE4A

Antigène: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Autre désignation: NSMCE4A (NSMCE4A Produits)

Synonymes: anticorps 2410003A14Rik, anticorps RGD1309025, anticorps C10orf86, anticorps NS4EA, anticorps NSE4A, anticorps NSE4 homolog A, SMC5-SMC6 complex component, anticorps Nsmce4a, anticorps NSMCE4A

Sujet: NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.
Alias Symbols: C10orf86, NS4EA, NSE4A
Protein Interaction Partner: UBC, HECW2, SRPK2, SRPK1, MAGED4B, NDNL2, MAGEC2, MAGEH1, MAGED2, NDN, MAGEB1, MAGEA1, NSMCE1, SMC6,
Protein Size: 385

Poids moléculaire: 44 kDa

ID gène: 54780

NCBI Accession: NM_017615, NP_060085

UniProt: Q9NXX6

Pathways: Positive Regulation of Response to DNA Damage Stimulus