TNFSF14 anticorps (Middle Region)

N° du produit ABIN2792133

Détail du produit anti-TNFSF14 anticorps

Antigène: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Épitope: Middle Region

Reactivité: Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNFSF14 est non-conjugé

Application: Western Blotting (WB)

Séquence: ATSSSRVWWD SSFLGGVVHL EAGEKVVVRV LDERLVRLRD GTRSYFGAFM

Homologie: Dog: 92%

Attributs du produit: This is a rabbit polyclonal antibody against TNFSF14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TNFSF14

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 240 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TNFSF14

Antigène: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Autre désignation: TNFSF14 (TNFSF14 Produits)

Synonymes: anticorps TNFSF14, anticorps CD258, anticorps HVEML, anticorps LIGHT, anticorps LTg, anticorps TR2, anticorps HVEM-L, anticorps Ly113, anticorps TNF superfamily member 14, anticorps tumor necrosis factor (ligand) superfamily, member 14, anticorps TNFSF14, anticorps Tnfsf14

Sujet: TNFSF14 is the cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B TNFSF14 modulates its effects. TNFSF14 activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. TNFSF14 acts as a receptor for Herpes simplex virus.The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Alias Symbols: CD258, HVEML, LIGHT, LTg, TR2
Protein Interaction Partner: APP, TNFRSF6B, TNFRSF14, LTBR, LTB, DIABLO, TRAF3, TRAF2, BIRC2,
Protein Size: 240

Poids moléculaire: 22 kDa

ID gène: 8740

NCBI Accession: NM_003807, NP_003798

UniProt: O43557

Pathways: Cancer Immune Checkpoints