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BBS5 anticorps (Center)

BBS5 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2796293
  • Antigène Voir toutes BBS5 Anticorps
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Épitope
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 108-141, Center
    Reactivité
    • 15
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 12
    • 3
    Lapin
    Clonalité
    • 14
    • 1
    Polyclonal
    Conjugué
    • 12
    • 1
    • 1
    • 1
    Cet anticorp BBS5 est non-conjugé
    Application
    • 11
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit Anti-Human BBS5 (Center) Antibody
    Immunogène
    This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BBS5 Anticorps primaire
  • Indications d'application
    Western Blot
    Recommended Dilutions
    WB: 1:1000Western blot analysis of lysate from K562 cell line, using BBS5 Antibody (Center) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 μg.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Stock
    4 °C,-20 °C
    Stockage commentaire
    2-8°C (short-term), -20°C (long-term)
  • Antigène
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Autre désignation
    BBS5 (BBS5 Produits)
    Synonymes
    anticorps zgc:56578, anticorps 1700049I01Rik, anticorps 2700023J09Rik, anticorps Bardet-Biedl syndrome 5, anticorps Bardet-Biedl syndrome 5 (human), anticorps bbs5, anticorps BBS5, anticorps Bbs5
    Sujet

    Target Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

    Gene Symbol: BBS5

    Poids moléculaire
    38755 Da
    ID gène
    129880
    UniProt
    Q8N3I7
    Pathways
    Signalisation Hedgehog
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