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SHC1 anticorps

SHC1 Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1944925
  • Antigène Voir toutes SHC1 Anticorps
    SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
    Reactivité
    • 168
    • 127
    • 89
    • 12
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 152
    • 23
    Lapin
    Clonalité
    • 151
    • 24
    Polyclonal
    Conjugué
    • 80
    • 10
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    Cet anticorp SHC1 est non-conjugé
    Application
    • 150
    • 56
    • 38
    • 25
    • 20
    • 14
    • 14
    • 14
    • 13
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Isotype
    IgG
    Top Product
    Discover our top product SHC1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Stock
    4 °C,-20 °C
  • Goshima, Kawamura, Fukumoto, Miura, Honma, Satoh, Wakamatsu, Yamamoto, Kimura, Nishikawa, Andoh, Iida, Ishikawa, Ito, Kagawa, Kaminaga, Kanehori, Kawakami, Kenmochi, Kimura, Kobayashi, Kuroita et al.: "Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. ..." dans: Nature methods, Vol. 5, Issue 12, pp. 1011-7, (2008) (PubMed).

    Migliaccio, Mele, Salcini, Pelicci, Lai, Superti-Furga, Pawson, Di Fiore, Lanfrancone, Pelicci: "Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway." dans: The EMBO journal, Vol. 16, Issue 4, pp. 706-16, (1997) (PubMed).

  • Antigène
    SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
    Autre désignation
    Shc (SHC1 Produits)
    Synonymes
    anticorps SHC1, anticorps SHC, anticorps SHCA, anticorps P66shc, anticorps si:dkey-246i14.4, anticorps wu:fc10h03, anticorps shc, anticorps p66shc, anticorps Shc, anticorps ShcA, anticorps p66, anticorps SHC adaptor protein 1, anticorps Shc1p, anticorps squalene--hopene cyclase, anticorps SHC (Src homology 2 domain containing) transforming protein 1, anticorps SHC (Src homology 2 domain containing) transforming protein 1 L homeolog, anticorps src homology 2 domain-containing transforming protein C1, anticorps SHC1, anticorps shc1, anticorps Shc1, anticorps shc1.L
    Sujet
    Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
    Poids moléculaire
    62822 Da
    ID gène
    6464
    UniProt
    P29353
    Pathways
    Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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