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SHC2 anticorps (AA 161-270) (Alexa Fluor 594)

SHC2 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 594
N° du produit ABIN2806350
  • Antigène Voir toutes SHC2 Anticorps
    SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
    Épitope
    • 14
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-270
    Reactivité
    • 25
    • 5
    • 4
    • 1
    Humain
    Hôte
    • 23
    • 3
    Lapin
    Clonalité
    • 24
    • 2
    Polyclonal
    Conjugué
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHC2 est conjugé à/à la Alexa Fluor 594
    Application
    • 12
    • 12
    • 12
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SHC2/Sck
    Isotype
    IgG
    Top Product
    Discover our top product SHC2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
    Autre désignation
    SHC2/Sck (SHC2 Produits)
    Synonymes
    anticorps SCK, anticorps SHCB, anticorps SLI, anticorps 6720466E06, anticorps ShcB, anticorps Sli, anticorps SHC adaptor protein 2, anticorps SHC (Src homology 2 domain containing) transforming protein 2, anticorps SHC2, anticorps Shc2
    Sujet

    Synonyms: Protein Sck, SCK, SH2 domain protein C2, SHC transforming protein 2, SHCB, Src homology 2 domain containing transforming protein C2, SHC2_HUMAN.

    Background: Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).

    Pathways
    Signalisation RTK, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, VEGF Signaling
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