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FRAT1 anticorps (AA 161-260) (Alexa Fluor 594)

FRAT1 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 594
N° du produit ABIN2813384
  • Antigène Voir toutes FRAT1 Anticorps
    FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
    Épitope
    • 14
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-260
    Reactivité
    • 24
    • 1
    Humain
    Hôte
    • 23
    • 1
    Lapin
    Clonalité
    • 23
    • 1
    Polyclonal
    Conjugué
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FRAT1 est conjugé à/à la Alexa Fluor 594
    Application
    • 24
    • 12
    • 12
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FRAT1
    Isotype
    IgG
    Top Product
    Discover our top product FRAT1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FRAT1 (Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
    Autre désignation
    FRAT1 (FRAT1 Produits)
    Synonymes
    anticorps FRAT1, anticorps frat1, anticorps AW060382, anticorps gbp, anticorps FRAT1, WNT signaling pathway regulator, anticorps GSK-3 binding protein FRAT1, anticorps frequently rearranged in advanced T cell lymphomas, anticorps frequently rearranged in advanced T-cell lymphomas, anticorps frequently rearranged in advanced T-cell lymphomas 1 S homeolog, anticorps FRAT1, anticorps frat1, anticorps Frat1, anticorps frat1.S
    Sujet

    Synonyms: FRAT 1, frequently rearranged in advanced T cell lymphomas, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, proto oncogene FRAT1, FRAT1_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    ID gène
    10023
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