PTPN23 anticorps (AA 1501-1636) (Alexa Fluor 594)

N° du produit ABIN2814234

Détail du produit anti-PTPN23 anticorps (Alexa Fluor 594)

Antigène: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Épitope: AA 1501-1636

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN23 est conjugé à/à la Alexa Fluor 594

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HDPTP

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PTPN23

Antigène: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Autre désignation: HDPTP (PTPN23 Produits)

Synonymes: anticorps HD-PTP, anticorps HDPTP, anticorps PTP-TD14, anticorps AI462446, anticorps Ptp-Td14, anticorps ptp23b, anticorps si:dkeyp-114f9.2, anticorps protein tyrosine phosphatase, non-receptor type 23, anticorps protein tyrosine phosphatase, non-receptor type 23, b, anticorps PTPN23, anticorps Ptpn23, anticorps ptpn23b

Sujet:

Synonyms: DKFZP564F0923, EC 3.1.3.48, HD PTP, HD-PTP, HDPTP, His domain containing protein tyrosine phosphatase, His domain protein tyrosine phosphatase, His domain-containing protein tyrosine phosphatase, KIAA1471, Protein tyrosine phosphatase non receptor type 23, protein tyrosine phosphatase non-receptor type 23, Protein tyrosine phosphatase TD 14, protein tyrosine phosphatase TD14, PTN23_HUMAN, PTP TD14, PTP-TD14, PTPN 23, PTPN23, Tyrosine protein phosphatase non receptor type 23, Tyrosine-protein phosphatase non-receptor type 23.

Background: HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

ID gène: 25930