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GLA anticorps

KO Validated GLA Reactivité: Humain WB, IP, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2854962
  • Antigène Voir toutes GLA Anticorps
    GLA (Galactosidase, alpha (GLA))
    Reactivité
    • 56
    • 30
    • 20
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 67
    • 8
    • 2
    Lapin
    Clonalité
    • 70
    • 7
    Polyclonal
    Conjugué
    • 33
    • 13
    • 12
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GLA est non-conjugé
    Application
    • 63
    • 34
    • 17
    • 17
    • 13
    • 13
    • 8
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    Knockdown/Knockout validation was supported by customer review data.
     Réactivité croisée
    Humain, Rat
    Attributs du produit
    Rabbit Polyclonal antibody to Galactosidase alpha (galactosidase, alpha)
    Galactosidase alpha antibody [N1C2]
    Purification
    Purified by antigen-affinity chromatography.
    Classe de qualité
    KO Validated
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product GLA Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: HeLa , 293T , Rat lung

    Validation: KO/KD

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.157 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." dans: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

    Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." dans: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

  • Antigène
    GLA (Galactosidase, alpha (GLA))
    Autre désignation
    galactosidase alpha (GLA Produits)
    Synonymes
    anticorps GALA, anticorps Ags, anticorps zgc:101584, anticorps MGC130872, anticorps SMU.877, anticorps SCF11.21, anticorps AO090005000217, anticorps alpha-GAL, anticorps galactosidase alpha, anticorps galactosidase, alpha, anticorps galactosidase alpha S homeolog, anticorps alpha-galactosidase, anticorps aga, anticorps alpha-galactosidase A, anticorps GLA, anticorps Gla, anticorps gla, anticorps gla.S, anticorps agaN, anticorps aga, anticorps agaL, anticorps SCO0541, anticorps rafA, anticorps melA, anticorps galA, anticorps ANI_1_2528074, anticorps ANI_1_1502124, anticorps AOR_1_390174, anticorps CpipJ_CPIJ002066, anticorps MCYG_00962, anticorps MCYG_00791, anticorps Tsp_02909, anticorps Tsp_02508
    Sujet
    This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

    Cellular Localization: Lysosome
    Poids moléculaire
    49 kDa
    ID gène
    2717
    UniProt
    P06280
    Pathways
    SARS-CoV-2 Protein Interactome
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