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Complement Factor B anticorps

CFB Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2855659
  • Antigène Voir toutes Complement Factor B (CFB) Anticorps
    Complement Factor B (CFB)
    Reactivité
    • 70
    • 44
    • 35
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 90
    • 15
    • 2
    Lapin
    Clonalité
    • 91
    • 15
    • 1
    Polyclonal
    Conjugué
    • 45
    • 19
    • 15
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Complement Factor B est non-conjugé
    Application
    • 80
    • 39
    • 30
    • 16
    • 13
    • 13
    • 11
    • 10
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Rabbit Polyclonal antibody to Factor B (complement factor B)
    Factor B antibody [N2C2], Internal
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human Factor B. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product CFB Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Validation: Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.87 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Zhu, Yao, Duan, Xu, Cheng, Gao, Li, Yang, Liu, Yuan: "Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3." dans: International journal of molecular sciences, Vol. 21, Issue 4, (2020) (PubMed).

  • Antigène
    Complement Factor B (CFB)
    Autre désignation
    complement factor B (CFB Produits)
    Synonymes
    anticorps AHUS4, anticorps BF, anticorps BFD, anticorps CFAB, anticorps FB, anticorps FBI12, anticorps GBG, anticorps H2-Bf, anticorps PBF2, anticorps bf, anticorps Bf-1, anticorps Brre-Bf, anticorps zgc:114032, anticorps Bf, anticorps Sp152, anticorps bfb-A, anticorps Bf B, anticorps LOC397725, anticorps bf/c2, anticorps CFB, anticorps AI195813, anticorps AI255840, anticorps B, anticorps C2, anticorps Fb, anticorps Da1-24, anticorps complement factor B, anticorps complement factor B S homeolog, anticorps complement factor B L homeolog, anticorps CFB, anticorps cfb, anticorps bf, anticorps cfb.S, anticorps cfb.L, anticorps bf/c2, anticorps LOC100555981, anticorps Cfb
    Sujet
    This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

    Cellular Localization: Secreted
    Poids moléculaire
    86 kDa
    ID gène
    629
    UniProt
    P00751
    Pathways
    Système du Complément, Proton Transport, Ribonucleoside Biosynthetic Process
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