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P2RX7 anticorps (Center)

P2RX7 Reactivité: Humain, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2855803
  • Antigène Voir toutes P2RX7 Anticorps
    P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
    Épitope
    • 15
    • 11
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 57
    • 40
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Rat
    Hôte
    • 56
    • 2
    • 2
    • 1
    Lapin
    Clonalité
    • 57
    • 4
    Polyclonal
    Conjugué
    • 27
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp P2RX7 est non-conjugé
    Application
    • 47
    • 26
    • 23
    • 13
    • 13
    • 12
    • 10
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Souris, Boeuf (Vache)
    Réactivité croisée (Details)
    Mouse (82 %), Bovine (86 %)
    Attributs du produit
    Rabbit Polyclonal antibody to P2X7 (purinergic receptor P2X, ligand-gated ion channel, 7)
    P2X7 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the center region of human P2X7. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product P2RX7 Anticorps primaire
  • Indications d'application
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Commentaires

    Positive Control: A431 , Rat brain

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Xiao, Li, Zhang, Xu, Zhang: "Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis." dans: Cell biology international, Vol. 47, Issue 7, pp. 1183-1197, (2023) (PubMed).

  • Antigène
    P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
    Autre désignation
    P2X7 (P2RX7 Produits)
    Synonymes
    anticorps p2xr7, anticorps P2RX7, anticorps P2X7, anticorps AI467586, anticorps P2X(7), anticorps P2X7R, anticorps p2x7, anticorps purinergic receptor P2X 7, anticorps purinergic receptor P2X, ligand-gated ion channel, 7, anticorps P2X purinoceptor 7, anticorps P2RX7, anticorps p2rx7, anticorps LOC100458463, anticorps P2rx7
    Sujet
    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.

    Cellular Localization: Membrane, Multi-pass membrane protein
    Poids moléculaire
    69 kDa
    ID gène
    5027
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
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