HLA-DRB3 anticorps

N° du produit ABIN2856027

Détail du produit anti-HLA-DRB3 anticorps

Antigène: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DRB3 est non-conjugé

Application: Immunofluorescence (IF), Immunocytochemistry (ICC)

Réactivité croisée: Humain

Attributs du produit: Rabbit Polyclonal antibody to HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)
HLA-DRB3 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human HLA-DRB3. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur HLA-DRB3

Antigène: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Autre désignation: major histocompatibility complex, class II, DR beta 3 (HLA-DRB3 Produits)

Synonymes: anticorps HLA-DR3B, anticorps BLA-DRB3, anticorps Bota-DRB01, anticorps Bota-DRB02, anticorps Bota-DRB04, anticorps Bota-DRB07, anticorps Bota-DRB21, anticorps Bota-DRB22, anticorps LA-DRB, anticorps major histocompatibility complex, class II, DR beta 3, anticorps major histocompatibility complex, class II, DRB3, anticorps HLA-DRB3, anticorps BOLA-DRB3

Sujet: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Cellular Localization: Membrane

Poids moléculaire: 30 kDa

ID gène: 3125

UniProt: P79483

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints