IKBKB anticorps (C-Term)
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- Antigène Voir toutes IKBKB Anticorps
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IKBKB est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
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Rabbit Polyclonal antibody to IKK beta (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)
IKK beta antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogène
- Recombinant protein encompassing a sequence within the C-terminus region of human IKK beta. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product IKBKB Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Commentaires
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Positive Control: DDDDK-human IKBKB-transfected 293T , PC-12 , A431 , HeLa , HepG2
Validation: Overexpression
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.41 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Antigène
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- Autre désignation
- inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB Produits)
- Synonymes
- anticorps ikk-beta, anticorps ikk2, anticorps ikkb, anticorps ikkbeta, anticorps IKBKB, anticorps IKKB, anticorps CG4201, anticorps DIK, anticorps DLAK, anticorps DmIKK, anticorps DmIKKBeta, anticorps DmIKKb, anticorps DmIKKbeta, anticorps DmIkkbeta, anticorps Dmel\\CG4201, anticorps Dmikkb, anticorps Dmikkbeta, anticorps IK, anticorps IKK, anticorps IKK-beta, anticorps IKKb, anticorps IKKbeta, anticorps IRD-5, anticorps IRD5, anticorps Ik, anticorps Ikkb, anticorps Ikkbeta, anticorps Ird-5, anticorps Ird5, anticorps LRK, anticorps Lak, anticorps anon-89Bd, anticorps dIKK, anticorps dIKK-beta, anticorps dIKKbeta, anticorps dLak, anticorps dmIKKbeta, anticorps ikk, anticorps ird, anticorps ird5/DmIkk[beta], anticorps IKK2, anticorps NFKBIKB, anticorps AIM-1, anticorps AI132552, anticorps IKK-2, anticorps IKK[b], anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog, anticorps inhibitor of nuclear factor kappa B kinase subunit beta, anticorps I-kappaB kinase beta, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, anticorps inhibitor of kappaB kinase beta, anticorps ikbkb.L, anticorps IKBKB, anticorps ikbkb, anticorps IKKbeta, anticorps Ikbkb
- Sujet
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NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]
Cellular Localization: Cytoplasm - Poids moléculaire
- 87 kDa
- ID gène
- 3551
- UniProt
- O14920
- Pathways
- Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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