anticorps ABC33, anticorps EST277145, anticorps MOAT-C, anticorps MOATC, anticorps MRP5, anticorps SMRP, anticorps pABC11, anticorps 2900011L11Rik, anticorps AI132311, anticorps Abcc5a, anticorps Abcc5b, anticorps Mrp5, anticorps abc33, anticorps abcc5, anticorps moat-c, anticorps moatc, anticorps mrp5, anticorps pabc11, anticorps smrp, anticorps ATP binding cassette subfamily C member 5, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 5, anticorps ATP binding cassette subfamily C member 5 L homeolog, anticorps ABCC5, anticorps Abcc5, anticorps abcc5.L
Sujet
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.,ABCC5,ABC33,EST277145,MOAT-C,MOATC,MRP5,SMRP,pABC11,Cancer,Signal Transduction,Endocrine & Metabolism,ABCC5