Perforin 1 anticorps (AA 280-555)

N° du produit ABIN3020642

Détail du produit anti-Perforin 1 anticorps

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Épitope: AA 280-555

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Perforin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: EEKKKKHKMT ASFHQTYRER HSEVVGGHHT SINDLLFGIQ AGPEQYSAWV NSLPGSPGLV DYTLEPLHVL LDSQDPRREA LRRALSQYLT DRARWRDCSR PCPPGRQKSP RDPCQCVCHG SAVTTQDCCP RQRGLAQLEV TFIQAWGLWG DWFTATDAYV KLFFGGQELR TSTVWDNNNP IWSVRLDFGD VLLATGGPLR LQVWDQDSGR DDDLLGTCDQ APKSGSHEVR CNLNHGHLKF RYHARCLPHL GGGTCLDYVP QMLLGEPPGN RSGAVW

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_001076585.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Perforin 1

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Autre désignation: PRF1 (PRF1 Produits)

Synonymes: anticorps FLH2, anticorps HPLH2, anticorps P1, anticorps PFN1, anticorps PFP, anticorps PRF1, anticorps Pfn, anticorps Pfp, anticorps Prf-1, anticorps Cyta, anticorps RATCYTA, anticorps LOC443187, anticorps perforin, anticorps prf1, anticorps cytolysin, anticorps perforin-1, anticorps perforin-1-like, anticorps perforin 1, anticorps perforin 1 (pore forming protein), anticorps perforin, anticorps perforin 1 L homeolog, anticorps PRF1, anticorps Prf1, anticorps LOC443187, anticorps prf1, anticorps prf1.L

Sujet: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.,PRF1,FLH2,HPLH2,P1,PFN1,PFP,perforin-1,Perforin,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,PRF1

Poids moléculaire: 61 kDa

ID gène: 5551

UniProt: P14222

Pathways: Apoptose, Caspase Cascade in Apoptosis