CDK4 anticorps (Cyclin-Dependent Kinase 4)

Details for Product anti-CDK4 Antibody No. ABIN3020965
Antigène
  • zgc:153726
  • CMM3
  • PSK-J3
  • Crk3
  • 8-6
  • CDK4
  • CDK4/6
  • CG5072
  • Cdk4/6
  • DmCdk4
  • Dmel\\CG5072
  • Pk53C
  • Pk?7
  • cdk
  • cdk4
  • cdk4/6
  • dCdk4
  • l(2)05428
  • l(2)0671
  • l(2)k06503
  • l(2)s4639
  • l(2)sh0671
  • xcdk4
  • cyclin-dependent kinase 4
  • cyclin dependent kinase 4
  • Cyclin-dependent kinase 4
  • cyclin-dependent kinase 4 L homeolog
  • cdk4
  • CDK4
  • Cdk4
  • cdk4.L
Reactivité
Souris, Rat (Rattus), Humain
268
135
108
20
9
6
6
5
5
1
1
1
Hôte
Lapin
201
97
4
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp CDK4 est non-conjugé
17
12
8
5
5
5
5
5
5
5
5
4
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
249
103
73
54
45
31
25
14
13
13
6
6
5
4
2
2
2
1
Options
Immunogène Center-peptide of human CDK4  
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others CDK4 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation CDK4 (CDK4 Antibody Extrait)
Sujet Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle.
Synonyms: CDK4, CMM3, MGC14458, PSK-J3
ID gène 1019
UniProt P11802
Pathways Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
Indications d'application Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze / thaw cycles
Stock -20 °C/-80 °C
Images (Fournisseur)
Image no. 1 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded rat liver using CDK4 Antibody.
Image no. 2 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Western blot analysis of extracts of various cell lines, using CDK4 antibody.
Image no. 3 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded human rectal cancer using CDK4 Antibody.
Image no. 4 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded rat lung using CDK4 Antibody.
Image no. 5 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded rat kidney using CDK4 Antibody.
Image no. 6 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded mouse kidney using CDK4 Antibody.
Image no. 7 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded human liver injury using CDK4 Antibody.
Image no. 8 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded rat liver using CDK4 Antibody.
Image no. 9 for anti-Cyclin-Dependent Kinase 4 (CDK4) antibody (ABIN3020965) Immunohistochemistry of paraffin-embedded human esophagus using CDK4 Antibody.
Produit citée dans: Cao, Liu, Huang, Wang, Jiao, Huo: "SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary." dans: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3115-3126, 2018 (PubMed). Méthode utilisée: Western Blotting (WB)

Qin, Zheng, Zhou, Ou, Huang, Yan, Qin, Yang, Su, Bai, Guo, Lin: "Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins." dans: Scientific reports, Vol. 6, pp. 19587, 2017 (PubMed). Méthode utilisée: Immunohistochemistry (IHC)

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