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RAN anticorps (AA 1-216)

RAN Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3021203
  • Antigène Voir toutes RAN Anticorps
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Épitope
    • 15
    • 15
    • 8
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-216
    Reactivité
    • 89
    • 46
    • 44
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 80
    • 7
    • 2
    Lapin
    Clonalité
    • 81
    • 7
    Polyclonal
    Conjugué
    • 44
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RAN est non-conjugé
    Application
    • 66
    • 34
    • 30
    • 26
    • 26
    • 17
    • 11
    • 11
    • 10
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Séquence
    MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL
     Réactivité croisée
    Humain, Singe, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human Ran (NP_006316.1).
    Isotype
    IgG
    Top Product
    Discover our top product RAN Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze / thaw cycles
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Autre désignation
    RAN (RAN Produits)
    Synonymes
    anticorps ARA24, anticorps Gsp1, anticorps TC4, anticorps ran, anticorps ara24, anticorps gsp1, anticorps ran-1, anticorps tc4, anticorps RAN, anticorps RANP1, anticorps AAF30287, anticorps CG1404, anticorps Dmel\CG1404, anticorps Ran, anticorps dran, anticorps l(1)G0075, anticorps ran10A, anticorps fc16b04, anticorps wu:fc16b04, anticorps RAN, member RAS oncogene family, anticorps RAN, member RAS oncogene family S homeolog, anticorps CG1404 gene product from transcript CG1404-RC, anticorps RAN, anticorps Ran, anticorps ran.S, anticorps ran
    Sujet
    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.,RAN,ARA24,Gsp1,TC4,Epigenetics & Nuclear Signaling,RNA Binding,Nuclear Receptor Signaling,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,RAN
    Poids moléculaire
    24 kDa
    ID gène
    5901
    UniProt
    P62826
    Pathways
    Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
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