IL1B anticorps (Interleukin 1, beta)

Details for Product anti-IL1B Antibody No. ABIN3021462
Antigène
  • il1-b
  • zgc:111873
  • IL-1beta
  • Il-1b
  • IL1B
  • IL-1
  • IL1-BETA
  • IL1F2
  • IL-1BETA
  • IL1beta
  • IL-1B
  • interleukin 1, beta
  • interleukin 1 beta
  • il1b
  • Il1b
  • IL1B
Reactivité
Souris, Rat (Rattus), Humain
351
166
120
37
23
21
16
14
13
11
9
9
8
4
4
2
2
1
Hôte
Lapin
421
174
15
8
8
8
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp IL1B est non-conjugé
84
35
23
12
6
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
444
340
193
67
65
56
43
36
33
31
31
23
22
16
14
5
4
4
3
3
3
3
2
2
2
1
1
1
1
Options
Immunogène Recombinant protein of human IL1B
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others IL1B products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation IL1B (IL1B Antibody Extrait)
Sujet The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28, and PA200 are three major protein Interleukin-1beta (IL-1beta), one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses. It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets. Human IL-1beta is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form. Detection of the 17 kDa mature form of IL-1beta is a good indicator of caspase-1 activity.
Synonyms: IL1B, IL-1, IL1-BETA, IL1F2 , IL1beta
ID gène 3553
UniProt P01584
Pathways Signalisation NF-kappaB, Interferon-gamma Pathway, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints
Indications d'application Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze / thaw cycles
Stock -20 °C/-80 °C
Images (Fournisseur)
Western Blotting (WB) image for anti-Interleukin 1, beta (IL1B) antibody (ABIN3021462) anti-Interleukin 1, beta (IL1B) antibody
Produit citée dans: Wu, Zhang, Qi, Zhang, Li, Li, Lin, Bai, Liu, Chen, Yang, Xu, Zhang, Yang: "Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis." dans: Cell death & disease, Vol. 9, Issue 2, pp. 171, 2018 (PubMed). Méthode utilisée: Western Blotting (WB)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." dans: Pharmacological research, Vol. 133, pp. 218-235, 2018 (PubMed). Méthode utilisée: ELISA (ELISA), Western Blotting (WB)

Zhou, Du, Liu, Zhao, Yuan, Li, Chen, Lu, Cheng, Liu: "Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity." dans: Life sciences, Vol. 204, pp. 55-64, 2018 (PubMed). Méthode utilisée: Western Blotting (WB), Immunofluorescence (IF)

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." dans: Frontiers in molecular neuroscience, Vol. 10, pp. 409, 2017 (PubMed). Méthode utilisée: Western Blotting (WB)

Wang, Shi, Dou, Li, Shi, Jiang, Wang, Yu, Chen, Wang, Xiao, Hou, Feng, Shen, Ma, Han: "Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis." dans: Immunology, Vol. 153, Issue 1, pp. 71-83, 2017 (PubMed). Méthode utilisée: ELISA (ELISA)

Liu, Zhang, Cheng, Lu, Liu: "Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response." dans: International journal of nanomedicine, Vol. 11, pp. 4875-4890, 2017 (PubMed). Méthode utilisée: Western Blotting (WB)

Yang, Zhang, Wang, Zhang, Li: "Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis." dans: Journal of periodontal research, Vol. 50, Issue 6, pp. 748-57, 2017 (PubMed). Méthode utilisée: Western Blotting (WB)

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