CLEC4E anticorps (C-Term)

N° du produit ABIN3024557

Détail du produit anti-CLEC4E anticorps

Antigène: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLEC4E est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A affinity chromatography

Immunogène: A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.\. Western blot: 2-5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CLEC4E antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CLEC4E

Antigène: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Autre désignation: CLEC4E (CLEC4E Produits)

Synonymes: anticorps CLECSF9, anticorps MINCLE, anticorps C86253, anticorps Clecsf9, anticorps Mincle, anticorps CLEC4E, anticorps C-type lectin domain family 4 member E, anticorps C-type lectin domain family 4, member e, anticorps C-type lectin domain family 4, member E, anticorps CLEC4E, anticorps Clec4e, anticorps LOC611538

Sujet: CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130  kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.

ID gène: 26253