IL2RG anticorps (Middle Region)

N° du produit ABIN3029733

Détail du produit anti-IL2RG anticorps

Antigène: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL2RG est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human IL-2 Receptor gamma subunit (HYWYKNSDNDKVQKC) was used as the immunogen for this IL-2 Receptor antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the IL-2 Receptor gamma antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the IL-2 Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur IL2RG

Antigène: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Autre désignation: IL-2 Receptor (Gamma Subunit) (IL2RG Produits)

Synonymes: anticorps Ab2-183, anticorps Cd132, anticorps CD132, anticorps CIDX, anticorps IL-2RG, anticorps IMD4, anticorps P64, anticorps SCIDX, anticorps SCIDX1, anticorps [g]c, anticorps gamma(c), anticorps gc, anticorps interleukin 2 receptor subunit gamma, anticorps interleukin 2 receptor subunit gamma L homeolog, anticorps interleukin 2 receptor, gamma chain, anticorps IL2RG, anticorps il2rg.L, anticorps Il2rg

Sujet: Interleukin 2 receptor gamma, also known as Common gamma chain or CD132, is a cytokine recepter subunit that is common to the receptr complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 recepter. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte(white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, the IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL-2 receptor. Lymphocytes expressing the common gama chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation. The sharing of the gama subunit by several receptors explains why humans and mice that lack IL-2 entirely show milder symptoms than those with IL2RG deficiency.

UniProt: P31785

Pathways: Signalistation JAK/STAT, Growth Factor Binding