Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
Antigen affinity
Immunogène
An amino acid sequence from the N-terminus of human Amyloid-precursor-like protein 1 (ELQIARVEQATQAIPMERWC) was used as the immunogen for this APLP1 antibody.
APLP1
Reactivité: Humain, Souris, Rat
WB, ELISA, IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
The stated application concentrations are suggested starting amounts. Titration of the APLP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the APLP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
APLP1
(Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))
anticorps aplp, anticorps MGC115336, anticorps APLP, anticorps Aplp1_retired, anticorps RGD1561211, anticorps amyloid beta precursor like protein 1, anticorps amyloid beta precursor like protein 1 L homeolog, anticorps amyloid beta (A4) precursor-like protein 1, anticorps APLP1, anticorps aplp1.L, anticorps aplp1, anticorps Aplp1
Sujet
Amyloid-precursor-like protein 1 is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimers disease. APLP1 is predominantly expressed in brain, particularly in the cerebral cortex postsynaptic density. The human gene has been mapped to chromosomal region 19q13.1. The gene is 11.8 kb long and contains 17 exons. APLP1 has been considered a candidate gene for CNF. All exon regions of the gene were amplified by the polymerase chain reaction and sequenced from DNA of CNF patients. No differences were observed between CNF patients and controls, suggesting that mutations in APLP1 are not involved in the etiology of CNF.