An amino acid sequence from the middle region of human Bone Morphogenetic Protein Receptor Type IB (FCYFRYKRQETRPRYS) was used as the immunogen for this BMPR1B antibody.
The stated application concentrations are suggested starting amounts. Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the BMPR1B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
BMPR1B
(Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))
anticorps ALK6, anticorps BMPR-IB, anticorps FecB, anticorps alk-6, anticorps alk6, anticorps cdw293, anticorps alk6b, anticorps zgc:172219, anticorps BMPR1B, anticorps AI385617, anticorps ALK-6, anticorps AV355320, anticorps Acvrlk6, anticorps Alk6, anticorps BMPR-1B, anticorps CFK-43a, anticorps SKR6, anticorps BR1b, anticorps alk6tr, anticorps bmpr1b, anticorps zALK-6, anticorps zgc:92220, anticorps CDw293, anticorps BMP15, anticorps BMPRIB, anticorps RPK-1, anticorps bone morphogenetic protein receptor type 1B, anticorps bone morphogenetic protein receptor, type IBb, anticorps bone morphogenetic protein receptor, type 1B, anticorps bone morphogenetic protein receptor, type IBa, anticorps BMPR1B, anticorps bmpr1b, anticorps bmpr1bb, anticorps Bmpr1b, anticorps bmpr1ba
Sujet
Bone Morphogenetic Protein Receptor Type IB, also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. It is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.