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CDX2 anticorps (Caudal Type Homeobox 2) (AA 1-30) Primary Antibody

CDX2 Reactivité: Humain IHC, ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3030336
$493.63
Plus shipping costs $45.00
0.4 mL ABIN3030336
0.4 mL ABIN3030336
local_shipping Destination: Etats-Unis
Envoi sous 2 à 3 jours ouvrables
  • Antigène
    CDX2
    Épitope
    AA 1-30
    • 30
    • 24
    • 14
    • 11
    • 9
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivité
    Humain
    • 172
    • 68
    • 67
    • 15
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Hôte
    Lapin
    • 113
    • 50
    • 9
    Clonalité
    Polyclonal
    • 115
    • 56
    Conjugué
    Cet anticorp CDX2 est non-conjugé
    • 87
    • 12
    • 10
    • 8
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    • 108
    • 94
    • 44
    • 43
    • 27
    • 25
    • 21
    • 18
    • 16
    • 13
    • 11
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Réactivité croisée (Details)
    Expected species reactivity: Mouse
    Purification
    Purified
    Immunogène
    A portion of amino acids 1-30 from the human protein was used as the immunogen for this CDX2 antibody.
    Isotype
    Ig Fraction
  • Indications d'application
    Titration of the CDX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the CDX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    CDX2
    Autre désignation
    CDX2 (CDX2 Antibody Extrait)
    Synonymes
    CDX2, MGC130987, cdx3-like, CDX-3, CDX3, CDX-2, Cdx-2, caudal type homeobox 2, caudal type homeobox 2 L homeolog, caudal type homeo box 2, CDX2, cdx2.L, Cdx2
    Sujet
    The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87 % ) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4 %) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.
    UniProt
    Q99626
    Pathways
    Peptide Hormone Metabolism, Stem Cell Maintenance
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