CDX2 anticorps (Caudal Type Homeobox 2) (AA 1-30) Primary Antibody
CDX2 Reactivité: Humain IHC, ELISA, WB Hôte: Lapin Polyclonal
N° du produit ABIN3030336
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- AA 1-30
- Cet anticorp CDX2 est non-conjugé
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
- Réactivité croisée (Details)
- Expected species reactivity: Mouse
- A portion of amino acids 1-30 from the human protein was used as the immunogen for this CDX2 antibody.
- Ig Fraction
- Indications d'application
- Titration of the CDX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
- For Research Use only
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- -20 °C
- Stockage commentaire
- Aliquot the CDX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
- Autre désignation
- CDX2 (CDX2 Antibody Extrait)
- The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87 % ) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4 %) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.
- Peptide Hormone Metabolism, Stem Cell Maintenance
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