DCC anticorps (AA 162-178)
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- Antigène Voir toutes DCC Anticorps
- DCC (Deleted in Colorectal Carcinoma (DCC))
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Épitope
- AA 162-178
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DCC est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Antigen affinity
- Immunogène
- Amino acids 162-178 (EVIGEPMPTIHWQKNQQ-human) were used as the immunogen for this DCC antibody (100% mouse homology).
- Isotype
- IgG
- Top Product
- Discover our top product DCC Anticorps primaire
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- Indications d'application
- The stated application concentrations are suggested starting amounts. Titration of the DCC antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Stock
- -20 °C
- Stockage commentaire
- After reconstitution, the DCC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Antigène
- DCC (Deleted in Colorectal Carcinoma (DCC))
- Autre désignation
- DCC (DCC Produits)
- Synonymes
- anticorps CRC18, anticorps CRCR1, anticorps IGDCC1, anticorps MRMV1, anticorps DCC, anticorps zdcc, anticorps C030036D22Rik, anticorps Igdcc1, anticorps xdcc, anticorps XDCCa, anticorps dcca-A, anticorps Dcc, anticorps DCC netrin 1 receptor, anticorps deleted in colorectal carcinoma, anticorps netrin receptor DCC, anticorps DCC, anticorps dcc, anticorps Dcc, anticorps LOC100712666
- Sujet
- Deleted in Colorectal Carcinoma is also known as CRC18 or CRCR1. The gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in the gene can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the gene spans approximately 1.4 Mb. Vogelstein(1995) stated that the precise location of the gene was thought to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. The protein can be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. It may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable (for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al.(2001) concluded that it plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
- UniProt
- P43146
- Pathways
- Regulation of Cell Size
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