FER anticorps (Middle Region)

N° du produit ABIN3030923

Détail du produit anti-FER anticorps

Antigène: FER (FER Tyrosine Kinase (FER))

Épitope: Middle Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FER est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human FER (FSNIPQLIDHHYTTKQ) was used as the immunogen for this FER antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the FER antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the FER antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur FER

Antigène: FER (FER Tyrosine Kinase (FER))

Autre désignation: FER (FER Produits)

Synonymes: anticorps FerT, anticorps PPP1R74, anticorps TYK3, anticorps Fer, anticorps Flk, anticorps Flk_retired, anticorps AV082135, anticorps C330004K01Rik, anticorps Fert, anticorps FER tyrosine kinase, anticorps fer (fms/fps related) protein kinase, anticorps FER, anticorps Fer

Sujet: FPS/FES-Related tyrosine kinase, also known as TYK3, is an enzyme that in humans is encoded by the FER gene. FER protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that the protein mediates crosstalk between CDH2 and ITGB1. In FER mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that the protein has a role in regulating innate immunity.

UniProt: P16591