FOXP1 anticorps (C-Term)

N° du produit ABIN3030994

Détail du produit anti-FOXP1 anticorps

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human FOXP1 (HSPDFDHDRDYEDEPVNEDME) was used as the immunogen for this FOXP1 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the FOXP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the FOXP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur FOXP1

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Autre désignation: FOXP1 (FOXP1 Produits)

Synonymes: anticorps 12CC4, anticorps QRF1, anticorps hFKH1B, anticorps 3110052D19Rik, anticorps 4932443N09Rik, anticorps AI461938, anticorps AW494214, anticorps foxp1, anticorps im:7139058, anticorps wu:fc83a06, anticorps FOXP1, anticorps MGC145686, anticorps 12cc4, anticorps fkh1b, anticorps hspc215, anticorps qrf1, anticorps xlfoxp1, anticorps im:7146611, anticorps wu:fb97f01, anticorps zgc:154010, anticorps forkhead box P1, anticorps forkhead box P1b, anticorps forkhead box P1 S homeolog, anticorps forkhead box P1a, anticorps FOXP1, anticorps Foxp1, anticorps foxp1b, anticorps foxp1, anticorps foxp1.S, anticorps foxp1a

Sujet: Forkhead box P1 is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response