GRIN1/NMDAR1 anticorps (N-Term)

N° du produit ABIN3031070

Détail du produit anti-GRIN1/NMDAR1 anticorps

Antigène: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIN1/NMDAR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human NMDAR1 (RKHEQMFREAVNQANKRH) was used as the immunogen for this NMDAR1 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the NMDAR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the NMDAR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur GRIN1/NMDAR1

Antigène: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Autre désignation: NMDAR1 (GRIN1 Produits)

Synonymes: anticorps GluN1, anticorps MRD8, anticorps NMDA1, anticorps NMDAR1, anticorps NR1, anticorps nmda1, anticorps nmdar1, anticorps GB19253, anticorps GRIN1, anticorps NMD-R1, anticorps Z16, anticorps GluRdelta1, anticorps GluRzeta1, anticorps M100174, anticorps Nmdar, anticorps Rgsc174, anticorps NMDAR1.1, anticorps zgc:152678, anticorps glutamate ionotropic receptor NMDA type subunit 1, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog, anticorps NMDA receptor 1, anticorps G protein-regulated inducer of neurite outgrowth 1, anticorps glutamate receptor, ionotropic, NMDA1 (zeta 1), anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1a, anticorps GRIN1, anticorps grin1.S, anticorps grin1, anticorps Grin1, anticorps Nmdar1, anticorps Gprin1, anticorps grin1a

Sujet: The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor. NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.

UniProt: Q05586

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity