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PPP1R13L anticorps (Isoform 1)

PPP1R13L Reactivité: Humain, Souris, Chien, Boeuf (Vache) WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN303133
  • Antigène Voir toutes PPP1R13L Anticorps
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Épitope
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform 1
    Reactivité
    • 53
    • 21
    • 18
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Chien, Boeuf (Vache)
    Hôte
    • 49
    • 4
    Lapin
    Clonalité
    • 52
    • 1
    Polyclonal
    Conjugué
    • 28
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PPP1R13L est non-conjugé
    Application
    • 42
    • 16
    • 14
    • 14
    • 13
    • 10
    • 9
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    ,Species:Human, Bovine, Dog and Mouse.
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    Synthetic peptide corresponding to Amino Acids 780-797 of human iASPP (isoform 1) protein.
    Top Product
    Discover our top product PPP1R13L Anticorps primaire
  • Indications d'application
    Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Immunofluorescence. Western Blot (1/1000-1/5000). ELISA (1/40000-1/160000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.19 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C. Dilute only prior to immediate use.
  • Antigène
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Autre désignation
    PPP1R13L (PPP1R13L Produits)
    Synonymes
    anticorps AV260376, anticorps IASPP, anticorps Nkip1, anticorps wa3, anticorps zgc:113058, anticorps NKIP1, anticorps RAI, anticorps RAI4, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 13 like, anticorps protein phosphatase 1, regulatory subunit 13 like, anticorps protein phosphatase 1 regulatory subunit 13 like, anticorps protein phosphatase 1 regulatory subunit 13 like L homeolog, anticorps Ppp1r13l, anticorps ppp1r13l, anticorps PPP1R13L, anticorps ppp1r13l.L
    Sujet
    ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.Synonyms: IASPP, Inhibitor of ASPP protein, NFkB-interacting protein 1, NKIP1, PPP1R13B-like protein, PPP1R13BL, RAI, RelA-associated inhibitor
    ID gène
    10848
    NCBI Accession
    NP_001135974
    UniProt
    Q8WUF5
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