MRP1 anticorps

N° du produit ABIN3031671

Détail du produit anti-MRP1 anticorps

Antigène: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Amino acids LLQQRGLFYSMAKDAGLV (human) were used as the immunogen for this MRP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the MRP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the MRP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur MRP1

Antigène: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Autre désignation: MRP1 (MRP1 Produits)

Synonymes: anticorps Abcc1a, anticorps Avcc1a, anticorps Mrp, anticorps Mrp1, anticorps BTCC-1, anticorps DRAP-27, anticorps MIC3, anticorps MRP-1, anticorps TSPAN-29, anticorps TSPAN29, anticorps Scya6, anticorps c10, anticorps ATP binding cassette subfamily C member 1, anticorps CD9 molecule, anticorps chemokine (C-C motif) ligand 6, anticorps Abcc1, anticorps CD9, anticorps Ccl6

Sujet: ABCC1 (ATP-binding cassette, subfamily C, member 1), also called MRP1, is a protein that in humans is encoded by the ABCC1 gene. ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. It is a plasma membrane drug-efflux pump.The gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1/MRP1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking MRP1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that it is an important protector in this scenario. The protein clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that MPR1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

UniProt: P33527

Pathways: Response to Water Deprivation, Cell-Cell Junction Organization